Allah Most High, mentioning His and the Messenger's opponents in the holy Quran, says: -

It is stated in the Tafsir-e-Ibn Kathir that those who oppose Allah and His messenger's commandments and are obstinate regarding the orders of the Shari' ah deserve disgrace, misfortune and damnation. Even as the people before them were ruined and abased for similar actions, they too will be destroyed and abased for the same contumacy. Such clear, open and explicit verses have been given, and tokens revealed that none save those who nurse a sentiment of stubbornness and malice can deny them and he who denies is a disbeliever. Besides, disgrace in this world for such disbelievers there are disparaging tortures in the hereafter also. Here their arrogance prevented them from bowing before their Lord; there they will be put to utmost disgrace and will be thoroughly trampled. The Quran further states: -

That is, the people who have turned their backs upon the truth and are away from guidance; those who are Allah's and His messenger's opponents, and are aloof from obeying the commandments of the Shari'ah, they are extremely abject, without honour and wretched. They are remote from the Lord's mercy, screened from Allah's affectionate glances and ruined in the world and the Hereafter. Allah Most High has decided and written in His Book and destined it - the decree and the writing which is ineffaceable and immutable, nor has anyone the power to change it - that Allah and His messenger and His believing slaves will be dominant in the world and the Hereafter as it has been mentioned at another place in the Quran: -

Similarly, what more severe prophetic statement is there regarding disobedience to Allah as it is stated in a hadith reported by Safwan bin Umayyah: -

We were in the Holy Prophet's  company when Amr bin Qurrah came. He said: "0 Apostle of Allah! Misery has been ordained for me. I think that my livelihood consists in this only that I play upon the tambourine. Now kindly permit me to sing such songs that may not have any obscene matter." The Holy Prophet  said: "I cannot permit you this. Neither have you any honour in my eyes nor do I feel pleased on meeting you. 0 enemy of Allah! You lie. Allah gave you legitimate livelihood but you left it and adopted the illegitimate living. Had I forbidden you earlier, I would have surely punished you now. Get up and be gone from here. Take a vow not to do it anymore and listen: ‘Now that I have warned you, if you do it again, I'll punish you black and blue. To deform your appearance, I'll have you tonsured and have you turned out from your household and I'll permit the young urchins of Madina to plunder all your goods." Hearing this Amr bin Qurrah got up and Allah Alone knows well how much evil must have been in his heart and how much disgrace and shame he must have felt. When he had gone, the Holy Prophet  said: "They are the disobedient people; they are those who shun Allah's commandments. If any one of them dies without repentance (taubah), Allah, on the Day of Judgement, will resurrect him in the same condition in which he was in the world - he will be a eunuch. His body will be naked, not having even a small piece of cloth on it so as to hide him from the people's eyes. And whenever he will stand up, he will topple down."